Sickle Cell Disease is an inherited disease in which two mutated hemoglobin genes result in misshapen red blood cells that block the circulation and thereby block oxygen delivery to key organs of the body. Sickle cell disease affects millions of people worldwide causing a lifetime of health problems including acute pain, severe anemia, stroke, infections, and vascular blockages that can lead to widespread organ damage and death.


Beta-thalassemia is a disease characterized by genetic mutations, including point mutations and gene deletions, in the hemoglobin gene. These genetic abnormalities result in reduced or absent synthesis of hemoglobin. Patients suffer with symptoms including anemia, fatigue, and blood clots.


Malaria is a mosquito-borne infectious disease caused by a parasite of the genus Plasmodium. In humans, parasites travel first to the liver and then to the red blood cells where they multiply. The parasite destroys infected red blood cells, releasing hemoglobin into the circulation and causing anemia. In a severe form of malaria caused by the parasite Plasmodium Falciparum, infected red blood cells stick to blood vessel walls and occlude blood flow resulting in organ dysfunction. This disease is common and a major health concern in tropical and subtropical areas of the world.


Developing Cures for Global Diseases


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